Revolutionizing protein analysis — from discovery to disease
We convert amino-acid information into DNA-based readouts that can be measured on any standard DNA platform — making biomarker analysis simple, quantitative and affordable.
Accelerating disease research by simplifying biomarker analysis
Pathmaker Bio's mission is to accelerate disease research by dramatically simplifying protein and peptide biomarker analysis — making it cost-effective and easy to adopt.
Instrumentation-free by design
Our method converts amino-acid information into DNA-based readouts that can be read on any DNA readout platform — removing the need for specialized proteomics instruments.
Cost-effective & easy to adopt
A simple benchtop workflow that integrates seamlessly with widely accessible DNA analysis platforms, so labs can start measuring proteins with tools they already run.
Conversomes™ reverse-translate peptides into DNA
Pathmaker Bio is developing a novel, patented class of molecules called Conversomes™. These molecules identify and "reverse-translate" peptide sequences into DNA readouts, while also detecting post-translational modifications.
During the assay, the process generates a stretch of oligonucleotide known as a pDNA™ sequence. This sequence serves as a surrogate readout for the target protein or peptide and can be analyzed on any standard DNA analysis platform.
By converting protein information into DNA, this chemistry enables rapid, highly quantitative protein detection. The same proprietary chemistry can generate on-demand synthetic antibodies — custom affinity reagents tailored to any specific protein or peptide sequence.
The entire workflow is a simple benchtop process that integrates with widely accessible DNA platforms, including qPCR and NGS.
One chemistry, many measurements
From multiplexed panels to bespoke affinity reagents, the Conversome™ platform adapts to the questions disease research needs answered.
Panels of target proteins
Analyze multiplexed panels of target proteins in a single benchtop assay, with DNA-based quantification.
Affinity reagents — synthetic "antibodies"
Generate on-demand custom affinity reagents tailored to any target protein or peptide sequence.
Proteoform analysis
Resolve proteoforms by reading sequence variation and post-translational modifications directly from the pDNA™ readout.
The Pathmaker Bio Conversion™ Kit
Everything needed to turn protein information into a DNA readout, formulated and ready for the bench.
Pathmaker Bio Conversion™ Kit
A complete benchtop kit for converting target proteins and peptides into pDNA™ readouts, compatible with qPCR and NGS instruments already in your lab.
Proprietary Conversome™ reagents
Conversion™ Kit reagents include proprietary Conversome™ and Oligoconversome™ molecules to generate pDNA™. Each is pre-formulated with unique Ligamers™ and Decodons™.
Get in touch
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